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LPA2 antagonist 2
CAS No. 36840-10-5
LPA2 antagonist 2( —— )
Catalog No. M32997 CAS No. 36840-10-5
LPA2 antagonist 2 is a selective and potent LPA2 antagonist (IC50: 28.3 nM) with potential anticancer activity, inhibits LPA3, and can be used in the study of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 227 | In Stock |
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| 10MG | 359 | In Stock |
|
| 25MG | 595 | In Stock |
|
| 50MG | 821 | In Stock |
|
| 100MG | 1107 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLPA2 antagonist 2
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NoteResearch use only, not for human use.
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Brief DescriptionLPA2 antagonist 2 is a selective and potent LPA2 antagonist (IC50: 28.3 nM) with potential anticancer activity, inhibits LPA3, and can be used in the study of cancer.
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DescriptionLPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).
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In VitroLysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA1 with an Imax of 59.0% at 30 μM.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetLPA Receptor
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RecptorLPA Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number36840-10-5
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Formula Weight380.35
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Molecular FormulaC20H16N2O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (219.09 mM; Ultrasonic )
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SMILESO=C(O)C=CC(=O)NC=1C=CC(=CC1)C2=CC=C(C=C2)NC(=O)C=CC(=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fells JI, et al. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17.?
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