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Home - Products - MAPK/ERK Signaling - JNK - J30-8

J30-8

CAS No. 2366255-71-0

J30-8( —— )

Catalog No. M32969 CAS No. 2366255-71-0

J30-8 is a subtype-selective and potent JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity for the study of neurodegenerative diseases such as Alzheimer's disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    J30-8
  • Note
    Research use only, not for human use.
  • Brief Description
    J30-8 is a subtype-selective and potent JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity for the study of neurodegenerative diseases such as Alzheimer's disease.
  • Description
    J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    JNK
  • Recptor
    JNK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2366255-71-0
  • Formula Weight
    373.79
  • Molecular Formula
    C17H9ClFN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.67 mg/mL (17.84 mM; Ultrasonic (<60°C)
  • SMILES
    Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N/c3ccccc3Cl)c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664.?
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