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HIF-2α-IN-3

CAS No. 313964-19-1

HIF-2α-IN-3( —— )

Catalog No. M32959 CAS No. 313964-19-1

HIF-2α-IN-3 is a HIF-2α alteration inhibitor with anti-tumor properties and may be used in the study of cardiovascular disease.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

HIF-2α-IN-3
Note

Research use only, not for human use.
Brief Description

HIF-2α-IN-3 is a HIF-2α alteration inhibitor with anti-tumor properties and may be used in the study of cardiovascular disease.
Description

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent.
In Vitro

HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain.
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

HIF
Research Area

——
Indication

——

Chemical Information

CAS Number

313964-19-1
Formula Weight

335.66
Molecular Formula

C12H6ClN5O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 12.5 mg/mL (37.24 mM; Ultrasonic )
SMILES

[O-][N+](=O)c1cc(Nc2ccc3nonc3c2[N+]([O-])=O)ccc1Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.?

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