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Glutaminase-IN-1
CAS No. 2247127-79-1
Glutaminase-IN-1( —— )
Catalog No. M32940 CAS No. 2247127-79-1
Glutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine inhibitor of the renal-type glutaminase (KGA) variant, exhibited antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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Biological Information
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Product NameGlutaminase-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionGlutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine inhibitor of the renal-type glutaminase (KGA) variant, exhibited antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.
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DescriptionGlutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptortransporter
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Research Area——
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Indication——
Chemical Information
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CAS Number2247127-79-1
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Formula Weight618.47
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Molecular FormulaC26H24F3N7O3Se
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (202.11 mM; Ultrasonic ) H2O : 2 mg/mL (3.23 mM; Ultrasonic (<60°C)
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SMILESC(C(NC1=CC=C(CCCCC=2[Se]C(NC(CC3=CC=CC=N3)=O)=NN2)N=N1)=O)C4=CC(OC(F)(F)F)=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Cltrinin
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.
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P7C3-OMe
P7C3-OMe, a pro-neurogenic agent, has therapeutic benefits in neurodegenerative diseases. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer.
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Allura Red AC
Allura Red AC is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.
