DO34( —— )

Catalog No. M32892 CAS No. 1848233-58-8

DO34 is a selective and potent diacylglycerol lipase (DAGL-α/β) inhibitor that impairs fear extinction in mice, and can be used to study lipopolysaccharide inflammatory pain.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

DO34
Note

Research use only, not for human use.
Brief Description

DO34 is a selective and potent diacylglycerol lipase (DAGL-α/β) inhibitor that impairs fear extinction in mice, and can be used to study lipopolysaccharide inflammatory pain.
Description

DO34 is a highly potent, selective and centrally active diacylglycerol lipase (DAGL) inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, and an IC50 for DAGLβ.
In Vitro

DO34 is a highly potent, selective and centrally active DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, as determined using a real-time, fluorescence-based natural substrate assay with membrane lysates from HEK293T cells expressing recombinant human DAGLα. It is also confirmed that and DO34 is a potent inhibitor of DAGLβ with IC50 of 3-8 nM.
In Vivo

DO34 (compound 39) prevents fasting-induced refeeding of mice, which is typical cannabinoid CB1-receptor mediated behavior. DO34 (comound 39) reduces brain 2-AG levels in dose- and time dependent manner. DO34 could block the tonic CB1 activation. AM251 significantly increases basal PF-EPSCs in MAGL-TKO mice, and the effect of AM251 is blocked by the DAGL inhibitor DO34.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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Chemical Information

CAS Number

1848233-58-8
Formula Weight

531.53
Molecular Formula

C26H28F3N5O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 100 mg/mL (188.14 mM )
SMILES

O=C(OC(C)(C)C)N1CCN(C(=O)N2N=NC(=C2)C=3C=CC(OC(F)(F)F)=CC3)C(CC=4C=CC=CC4)C1
Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ogasawara D, et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.?

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