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Desformylflustrabromine hydrochloride
CAS No. 951322-11-5
Desformylflustrabromine hydrochloride( —— )
Catalog No. M32882 CAS No. 951322-11-5
Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 73 | In Stock |
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| 25MG | 148 | In Stock |
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| 50MG | 232 | In Stock |
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| 100MG | 365 | In Stock |
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| 200MG | 567 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDesformylflustrabromine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDesformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
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DescriptionDesformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.
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In VitroDesformyl flustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48. ACh-induced currents are potentiated and inhibited by Desformyl flustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform(pEC50=6.4±0.2) compare with the HS isoform (pEC50=5.6±0.2). Desformyl flustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%).
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number951322-11-5
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Formula Weight437.19
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Molecular FormulaC17H12INO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 105 mg/mL (293.53 mM) H2O : 5 mg/mL (13.98 mM; Ultrasonic)
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SMILESCl.CNCCc1c([nH]c2cc(Br)ccc12)C(C)(C)C=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nadezhda German, et al. Deconstruction of the α4β2 Nicotinic Acetylchloine (nACh) Receptor Positive Allosteric Modulator des-Formylflustrabromine (dFBr). J Med Chem. 2011 Oct 27;54(20):7259-67.?
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