Cot inhibitor-1( —— )

Catalog No. M32855 CAS No. 915365-57-0

Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Cot inhibitor-1
Note

Research use only, not for human use.
Brief Description

Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM.
Description

Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of5.7 nM.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

MAPK | TNF
Research Area

——
Indication

——

Chemical Information

CAS Number

915365-57-0
Formula Weight

553.46
Molecular Formula

C27H27Cl2FN8
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (45.17 mM; Ultrasonic )
SMILES

Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(CCN5CCCCCC5)nn4)cc23)C#N)cc1Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.?

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