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Cot inhibitor-1
CAS No. 915365-57-0
Cot inhibitor-1( —— )
Catalog No. M32855 CAS No. 915365-57-0
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 186 | In Stock |
|
| 5MG | 155 | In Stock |
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| 10MG | 235 | In Stock |
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| 25MG | 424 | In Stock |
|
| 50MG | 621 | In Stock |
|
| 100MG | 916 | In Stock |
|
| 200MG | 1256 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCot inhibitor-1
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NoteResearch use only, not for human use.
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Brief DescriptionCot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM.
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DescriptionCot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of5.7 nM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorMAPK | TNF
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Research Area——
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Indication——
Chemical Information
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CAS Number915365-57-0
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Formula Weight553.46
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Molecular FormulaC27H27Cl2FN8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (45.17 mM; Ultrasonic )
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SMILESFc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(CCN5CCCCCC5)nn4)cc23)C#N)cc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.?
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