COX-2-IN-2

CAS No. 134729-13-8

COX-2-IN-2( —— )

Catalog No. M32736 CAS No. 134729-13-8

COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 424 In Stock
5MG 416 In Stock
10MG 668 In Stock
25MG 1330 In Stock
50MG 2074 In Stock
100MG 2753 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    COX-2-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM.
  • Description
    COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
  • In Vitro
    COX-2-IN-2 shows no COX-1 inhibition even at 100μM.
  • In Vivo
    COX-2-IN-2 has oral ED50 values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis, respectively, and an ED30 value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    134729-13-8
  • Formula Weight
    341.36
  • Molecular Formula
    C17H12FN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(#N)C=1C=C(N(N1)C2=CC=C(F)C=C2)C3=CC=C(S(C)(=O)=O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsuji K, et al. Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives. Chem Pharm Bull (1997), 45(6), 987-995.
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