Justicidin A

Research use only, not for human use.

Justicidin A is a type of bioactive chemical from Justica procumbens.

Justicidin A is a type of bioactive chemical from Justica procumbens.

Cell Viability Assay Cell Line:HT-29, HCT 116, SiHa, MCF7 and T24 cells Concentration:0-2.5 μM Incubation Time:6 days Result:Inhibited cell growth in a dose-dependent manner.Apoptosis AnalysisCell Line:HT-29 and HCT 116 cells Concentration:0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells)Incubation Time:0, 12, 16, 20, 24, 48, and 72 hours Result:Induced apoptosis in a time-dependent manner.Increased the population of sub-G 1 cells in a time-dependent manner.Western Blot Analysis Cell Line:HT-29 and HCT 116 cells Concentration:0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells)Incubation Time:0, 12, 16, 20, 24, 48, 72, and 96 hours Result: Decreased the amount of cytosolic Ku70 in HCT 116 cells and decreased (0.6-fold) at 48 h and reached the lowest level (0.33-fold) at 96 h.Western Blot Analysis Cell Line:HT-29 and HCT 116 cells Concentration:0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells) Incubation Time:0, 12, 16, 20, 24, 48, and 72 hours Result:Induced the cleavage of caspases and their target proteins.

Animal Model:NOD-SCID mice with HT-29 cells xenograftes Dosage:6.2 mg/kg Administration:Oral administration; daily, for 56 days Result:Inhibited tumor growth and decreased tumor weight.

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Others

Other Targets

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25001-57-4

394.4

C22H18O7

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years