erythro-Austrobailignan-6( —— )

Catalog No. M32474 CAS No. 114127-24-1

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Product Name

erythro-Austrobailignan-6
Note

Research use only, not for human use.
Brief Description

erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK.
Description

erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .
In Vitro

Cell Viability Assay Cell Line:4T-1 and MCF-7 cells Concentration:0-30 μM Incubation Time:24 or 48 h Result:Dose dependently inhibited cell proliferation.Western Blot Analysis Cell Line:4T-1 and MCF-7 cells Concentration:100 μM Incubation Time:30, 60 or 120 min Result:Increased phosphorylation of p38 and JNK.Activated caspase-3 and inhibited CDK-4 and cyclin D1.
In Vivo

Animal Model:4T-1 tumor bearing mice Dosage:20 mg/kg/day Administration:Food intake Result:Inhibited tumor growth by 40.8%;Down-regulated CDK-4, cyclin D1, HER2 and integrin β3; Up-regulated cleaved caspase-3 in tumor.
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