4'-Methoxyresveratrol is a natural product form the roots of Rheum palmatum Lhas significant hypoglycemic anti-inflammatory and antioxidant effects.

Erythritol is a sugar alcohol used as low-calorie sweetener.

RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses.