Norswertianolin( —— )

Catalog No. M32238 CAS No. 54954-12-0

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Product Name

Norswertianolin
Note

Research use only, not for human use.
Brief Description

Norswertianolin, a compound isolated from G. acuta, functions as a CSE activator and shows promise as a potential cardiovascular therapeutic.
Description

Norswertianolin, a compound isolated from G. acuta, functions as a CSE activator and shows promise as a potential cardiovascular therapeutic.
In Vitro

Norswertianolin (3.125~50 μM; H9c2 cells) has the protective effects on H2O2-induced H9c2 cells. Norswertianolin significantly increases the transcription levels of HO-1 and GCLC in H9c2 cells. Norswertianolin (0~150 μM; HepG2 cells) high concentration increases the CSE protein level.
In Vivo

Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production.Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects. Animal Model:Male Sprague Dawley rats (10~12 weeks ) Dosage:4.4 mg/kg/day Administration:S.c.Result:Improved CSE/H2S production.
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