Pilocarpine

Research use only, not for human use.

Pilocarpine has been used to treat glaucoma, ocular hypertension and xerostomia. Pilocarpine can induce seizures.

Pilocarpine has been used to treat glaucoma, ocular hypertension and xerostomia. Pilocarpine can induce seizures. It antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. the ability of oral pilocarpine to normalise and reverse the salivary biochemical and immunological alterations induced by cGVHD parallels its known stimulatory effect on salivary flow rates. The combination of pilocarpine and sorbitol has effective antimicrobial activity.

To evaluate the cytotoxicity of Pilocarpine, the morphology and viability of human corneal stromal (HCS) cells are examined by light microscopy and MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- and time-dependent proliferation retardation and morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, and eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L and controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time and concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show no significant difference to controls. The partial muscarinic agonist, Pilocarpine, evokes concentration-dependent relaxation with an EC50 of 2.4 mM in isolated segments of rat tail artery that were constricted with Penylephrine (10 to 200 nM).

The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na+ concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).

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Others

Other Targets

Antifection | EGF

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92-13-7

208.3

C11H16N2O2

>98% (HPLC)

DMSO, Pyridine, Methanol, Ethanol, etc.

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(-20℃)

With Ice Pack

≥ 2 years