Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain. Crocin-4 can be used for the research of Alzheimer's Disease. Crocin-4 also exhibits antitumor and anti-inflammatory activities.

Methylamine occurs endogenously from amine catabolism and its tissue levels increase in some pathological conditions including diabetes.

TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM respectively).