Homatropine

Research use only, not for human use.

The herbs of Atropa belladonna L.

The herbs of Atropa belladonna L.

Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs.Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.

Homatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats. Animal Model:Male albino rats Dosage:9 mm x 5 mm conical suppository Administration:By suppository Result:Blocked cardiovascular responses to vagal stimulation and acetylcholine; 10-20 min after insertion of the suppository the effects of vagal stimulation over a range of 2-16 Hz, 5 V, on pulse rate was virtually abolished and remained unchanged at 45-60 min.

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Others

Other Targets

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87-00-3

275.4

C16H21NO3

>98% (HPLC)

DMSO, Pyridine, Methanol, Ethanol, etc.

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(-20℃)

With Ice Pack

≥ 2 years