Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway.

EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.

Colesevelam Hydrochloride is a bile acid sequestrant with a higher affinity for glycocholic acid in vitro. Colesevelam Hydrochloride inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduces cholesterol levels in patients.