(3R)-5,7-Dihydroxy-6-methyl-3-(4-hydroxybenzyl)chroman-4-one

Research use only, not for human use.

(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one is a natural product.

(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one is a natural product.

LPRP-Et-97543 (0.625-40 μg/ml; 3 days) causes cytotoxic effects at doses >10 μg/ml in HepG2.2.15 and HBV-transfected Huh7 cells.LPRP-Et-97543 (2.5-10 μg/ml; 3 days) has inhibitory effects on HBsAg and HBeAg secretions. And the HBeAg inhibition rate is higher than the HBsAg inhibition rate in HepG2.2.15 cells.LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days)significantly reduces both precore/pregenomic and major S/preS RNA with the LPRP-Et-97543 inhibition potential higher on surface RNA than on the precore/pregenomic RNA.LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) potently reducesintracellular LHBsAg and HBcAg protein levels compared to vehicle controls. Additionally, LPRP-Et-97543 potently inhibits the replication HBV DNAlevel in HBV transfected Huh7 cells.LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) reduces nuclear p65/p50 NF-κB protein expression and reduces phosphorylated NF-κBp65 in Huh7 cells. Western Blot Analysis Cell Line:Huh7 cells with or without pHBV1.2 Concentration:2.5-10 μg/ml Incubation Time: 2 days Result:Decreased nuclear and nuclear p-p65 expression and increased cytoplasmic IκBα expression.

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Others

Other Targets

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84638-48-2

300.3

C17H16O5

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years