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Pendulone
CAS No. 69359-09-7
Pendulone( —— )
Catalog No. M31731 CAS No. 69359-09-7
Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePendulone
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NoteResearch use only, not for human use.
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Brief DescriptionPendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
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DescriptionPendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
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In VitroPendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50 value 19.6 μM.Pendulone displays an IC50 value of 0.43 μg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 of 1.44 μg/mL). Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50 values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11). Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells.
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In VivoPendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number69359-09-7
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Formula Weight316.31
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Molecular FormulaC17H16O6
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Rhodiocyanoside A
Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP IgE and inhibits the PCA reaction in rats.
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8-Hydroxygenistein
8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O??). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein. The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.
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