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Home - Products - GPCR/G Protein - Antibacterial - LL-37, Human

LL-37, Human

CAS No. 154947-66-7

LL-37, Human( —— )

Catalog No. M30473 CAS No. 154947-66-7

LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    LL-37, Human
  • Note
    Research use only, not for human use.
  • Brief Description
    LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.
  • Description
    LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.
  • In Vitro
    LL-37, human (1-20 μg/mL; 24 h) affects HCECs migration.LL-37, human (0.0001-5 μg/mL;6-24 h) affects cytokine secretion in HCECs.LL-37, human (1-100 μg/mL; 24 h) shows dose-dependently cytotoxic to HCECs at concentrations over 10 μg /mL. Cell Migration Assay Cell Line:Human corneal epithelial cell (HCEC)Concentration:1, 2.5, 5, 10 and 20 μg/mL Incubation Time:24 hoursResult:Dose-dependently stimulated HCEC migration but showed no effect on cell proliferation.Cell Viability Assay Cell Line:Human corneal epithelial cell (HCEC) Concentration:0.0001, 0.001, 0.01, 0.1, 0.5, 1, and 5 μg/mL Incubation Time:6 and 24 hours Result:Dose-dependently increased IL-8, IL-6, IL-1β and TNF-α secretion at 6 and 24 hours in HCEC.
  • In Vivo
    LL-37, human (0.4-2.0 mg/kg; intratracheal injection once) ameliorates MRSA-induced pneumonia of mice. Animal Model:6-8 week-old C57BL/6 mice with MRSA-induced pneumonia Dosage:0.4, 0.8, 1.2, 1.6 and 2.0 mg/kg Administration:Intratracheal injection; 0.4-2.0 mg/kg once Result:Decreased IL-6 and TNF-α release to attenuated MRSA-induced pneumonia of testing mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    154947-66-7
  • Formula Weight
    4493.26
  • Molecular Formula
    C205H340N60O53
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (11.13 mM)
  • SMILES
    ——
  • Chemical Name
    Sequence:{Leu}{Leu}{Gly}{Asp}{Phe}{Phe}{Arg}{Lys}{Ser}{Lys}{Glu}{Lys}{Ile}{Gly}{Lys}{Glu}{Phe}{Lys}{Arg}{Ile}{Val}{Gln}{Arg}{Ile}{Lys}{Asp}{Phe}{Leu}{Arg}{Asn}{Leu}{Val}{Pro}{Arg}{Thr}{Glu}{Ser}

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Dürr UH, et al. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta. 2006 Sep;1758(9):1408-25.
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