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DAMGO (TFA)

CAS No. 950492-85-0

DAMGO (TFA)( —— )

Catalog No. M30306 CAS No. 950492-85-0

DAMGO is a selective peptide agonist of the μ-opioid receptor .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DAMGO (TFA)
  • Note
    Research use only, not for human use.
  • Brief Description
    DAMGO is a selective peptide agonist of the μ-opioid receptor .
  • Description
    DAMGO is a selective peptide agonist of the μ-opioid receptor .
  • In Vitro
    DAMGO (1-10 μM) TFA significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression.DAMGO (1 μM) TFA effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO.
  • In Vivo
    DAMGO (i.v., 0.5-2 mg/kg) TFA can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    950492-85-0
  • Formula Weight
    627.61
  • Molecular Formula
    C28H36F3N5O8
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : 125 mg/mL (199.17 mM; Need ultrasonic)
  • SMILES
    ——
  • Chemical Name
    Sequence:Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

FEBS Lett. 1995 Jan 2;357(1):93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.
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