2-Furoyl-LIGRLO-amide

Research use only, not for human use.

2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.

2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.(In Vitro):2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively. In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries.

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Animal Model:Adult male (2/3-month-old) Trpv3-/- and WT mice Dosage:10 μg Administration:Injected intradermally at the nape of the neck Result:Was involved in PAR2- induced acute itch.

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GPCR/G Protein

PAR

Proteise-activated receptor 2 (PAR2)

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729589-58-6

777.95

C36H63N11O8

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (64.27 mM)

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Sequence:{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

(-20℃)

With Ice Pack

≥ 2 years