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KISS1-305
CAS No. 872717-97-0
KISS1-305( —— )
Catalog No. M30166 CAS No. 872717-97-0
KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation.KISS1-305 is a proto- type peptide that resists plasma protease degradation but has suboptimal KISS1R agonistic activity in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameKISS1-305
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NoteResearch use only, not for human use.
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Brief DescriptionKISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation.KISS1-305 is a proto- type peptide that resists plasma protease degradation but has suboptimal KISS1R agonistic activity in vitro.
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DescriptionKISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation.KISS1-305 is a proto- type peptide that resists plasma protease degradation but has suboptimal KISS1R agonistic activity in vitro.(In Vivo):KISS1-305 (4 nmol/h; s.c.) shows suppression of pituitary-gonadal functions. KISS1-305 causes substantial elevations of plasma LH and testosterone, followed by abrupt reductions of both hormone levels. KISS1-305 also reduced genital organ weight more profoundly than leuprolide. In mechanistic studies, chronic KISS1-305 administration only transiently induced c-Fos expression in GnRH neurons, suggesting that GnRH-neural response was attenuated over time.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number872717-97-0
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Formula Weight1165.3
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Molecular FormulaC56H76N16O12
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Matsui H, et al.Chronic?administration?of the?metastin/kisspeptin?analog?KISS1-305?or the?investigational?agent?TAK-448?suppresses?hypothalamic?pituitary?gonadal?function?and?depletes?plasma?testosterone?in?adult?male?rats.Endocrinology.?2012 Nov;153(11):5297-308.
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