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Home - Products - Others - Other Targets - Neurokinin A(4-10) TFA(97559-35-8 free base)

Neurokinin A(4-10) TFA(97559-35-8 free base)

CAS No. ——

Neurokinin A(4-10) TFA(97559-35-8 free base)( —— )

Catalog No. M30084 CAS No. ——

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Neurokinin A(4-10) TFA(97559-35-8 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.
  • Description
    Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.(In Vitro):Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NK2 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    880.93
  • Molecular Formula
    C36H55F3N8O12S
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : < 0.1 mg/mL (insoluble)
  • SMILES
    ——
  • Chemical Name
    Sequence:Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.
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