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Neurokinin A(4-10) TFA(97559-35-8 free base)
CAS No. ——
Neurokinin A(4-10) TFA(97559-35-8 free base)( —— )
Catalog No. M30084 CAS No. ——
Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameNeurokinin A(4-10) TFA(97559-35-8 free base)
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NoteResearch use only, not for human use.
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Brief DescriptionNeurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.
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DescriptionNeurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.(In Vitro):Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorNK2 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight880.93
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Molecular FormulaC36H55F3N8O12S
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Purity>98% (HPLC)
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SolubilityH2O : < 0.1 mg/mL (insoluble)
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SMILES——
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Chemical NameSequence:Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.
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