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Crosstide
CAS No. 171783-05-4
Crosstide( —— )
Catalog No. M30069 CAS No. 171783-05-4
Crosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) that functions as a natural substrate for Akt/PKB.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameCrosstide
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NoteResearch use only, not for human use.
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Brief DescriptionCrosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) that functions as a natural substrate for Akt/PKB.
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DescriptionCrosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) that functions as a natural substrate for Akt/PKB.(In Vitro):16HBE14o cells exposed to RV39 demonstrate a crosstide kinase activity in vitro. Serine phosphorylation of crosstide is confirmed by immunoblotting, and phosphorylation is blocked by PP2 but not by PP3. The wildtype GST-AKT2 shows significant phosphoryl transferase activity towards crosstide, reaching an initial velocity of 16 pmol phosphate/min/μg enzyme. The mutant GST-AKT2T/E,S/D displayed an initial velocity of 85 pmol phosphate/min/μg kinase for phosphorylation of Crosstide, corresponding to a 5-fold increase compared to the wildtype enzyme.
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In Vitro16HBE14o? cells exposed to RV39 demonstrate a crosstide kinase activity in vitro. Serine phosphorylation of crosstide is confirmed by immunoblotting, and phosphorylation is blocked by PP2 but not by PP3. The wildtype GST-AKT2 shows significant phosphoryl transferase activity towards crosstide, reaching an initial velocity of 16 pmol phosphate/min/μg enzyme. The mutant GST-AKT2T/E,S/D displayed an initial velocity of 85 pmol phosphate/min/μg kinase for phosphorylation of Crosstide, corresponding to a 5-fold increase compared to the wildtype enzyme.
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number171783-05-4
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Formula Weight1164.23
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Molecular FormulaC48H77N17O17
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Purity>98% (HPLC)
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SolubilityH2O : ≥ 50 mg/mL (42.95 mM)
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SMILES——
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Chemical NameSequence:Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Bentley JK, et al. Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells. J Virol. 2007 Feb;81(3):1186-94. Epub 2006 Nov 22.
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