JAK2-IN-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis. Antitumor activities.

JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).

NVP-BSK805 dihydrochloride is an effective and selective inhibitor of JAK2 with IC50s of 0.5 nM, 10.76 nM, 18.68 nM, and 31.63 nM for JAK2, TYK2, JAK3, and JAK1.