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Fz7-21 TFA (2247635-23-8 free base)

CAS No. ——

Fz7-21 TFA (2247635-23-8 free base)( (Ac)-LPSDDLEFWCHVMY-NH2 TFA )

Catalog No. M29961 CAS No. ——

Fz7-21 TFA ((Ac)-LPSDDLEFWCHVMY-NH2 TFA), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Fz7-21 TFA (2247635-23-8 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    Fz7-21 TFA ((Ac)-LPSDDLEFWCHVMY-NH2 TFA), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively.
  • Description
    Fz7-21 TFA ((Ac)-LPSDDLEFWCHVMY-NH2 TFA), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    (Ac)-LPSDDLEFWCHVMY-NH2 TFA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    1910.07
  • Molecular Formula
    C85H115N18F3O25S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Sequence:(Ac)-{Leu}{Pro}{Ser}{Asp}{Asp}{Leu}{Glu}{Phe}{Trp}{Cys}{His}{Val}{Met}{Tyr}-NH2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Nile AH, et al. Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.
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