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TAK-448
CAS No. 1234319-68-6
TAK-448( MVT-602 )
Catalog No. M29793 CAS No. 1234319-68-6
TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 332 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameTAK-448
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NoteResearch use only, not for human use.
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Brief DescriptionTAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
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DescriptionTAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.(In Vivo):TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model.
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In Vitro——
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In VivoTAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model. Animal Model:Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)Dosage:0.01, 0.03, 0.3, 3 mg/kg Administration:Given i.h.; dosings on day 0 and 28 Result:Had greater anti-tumor effects in VCaP xenograft model.
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SynonymsMVT-602
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PathwayOthers
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TargetOther Targets
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RecptorIC50: 460 pM (KISS1R)
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Research Area——
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Indication——
Chemical Information
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CAS Number1234319-68-6
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Formula Weight1225.36
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Molecular FormulaC58H80N16O14
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameSequence:Ac-D-Tyr-D-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811.
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