Aminomalonic acid (Ama) was first detected in alkaline hydrolysates of proteins in 1984. Ama has been isolated from proteins of Escherichia coli and human atherosclerotic plaque. The presence of Ama has important biological implications because the malonic acid moiety potentially imparts calcium binding properties to protein.

N-Acetylcadaverine is the acetylated form of the polyamine cadaverine. Cadaverine is produced by the breakdown of amino acids in living and dead organisms and is toxic in large doses. N-(5-Aminopentyl)acetamide is a promising biochemical marker for cancer and many other pathophysiological conditions.

KPT-6566 is a novel selective covalent pin1 inhibitor KPT-6566 shows an IC50 of 640?nM and a Ki of 625.2 nM for PIN1 PPIase domainand has anti-cancer activity.