Hydrangenol

Research use only, not for human use.

Hydrangenol is isolated from Hydrangea serrata leaves exerts antiphotoaging activity in vitro.

Hydrangenol is isolated from Hydrangea serrata leaves exerts antiphotoaging activity in vitro.(In Vitro):Hydrangenol increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Consistent with the recovery of collagen composition, the expression of Pro-COL1A1 was increased by hydrangenol.

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Animal Model:UVB-irradiated HR-1 hairless miceDosage:5, 10, 20, or 40 mg/kg Administration:Oral gavage; daily for 7 weeksResult:Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Increased the expression of Pro-COL1A1.Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6).Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1).Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).

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Immunology/Inflammation

NOS

NOS

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480-47-7

256.3

C15H12O4

>98% (HPLC)

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Oc1ccc(cc1)C1Cc2cccc(O)c2C(=O)O1

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(-20℃)

With Ice Pack

≥ 2 years