6,4'-Dihydroxy-7-methoxyflavanone

Research use only, not for human use.

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T.

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.(In Vitro):6,4'-Dihydroxy-7-methoxyflavanone showed inhibition of osteoclasts differentiation and function. 6,4'-Dihydroxy-7-methoxyflavanone increased cellular resistance to oxidative injury caused by glutamate-induced cytotoxicity in HT22 cells, via JUN N-terminal kinase (JNK) pathway dependent (HO)-1 expression. 6,4'-Dihydroxy-7-methoxyflavanone suppressed the lipopolysaccharide (LPS)-induced expression of pro-inflammatory enzymes and inflammatory mediators in BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone suppressed production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression. CONCLUSIONS: This study indicates that 6,4'-Dihydroxy-7-methoxyflavanone effectively modulates the regulation of anti-oxidative and anti-inflammatory action, via up-regulation of HO-1 in HT22 cells and BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone possesses therapeutic potentials against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation.

Western Blot Analysis Cell Line:Macrophages Concentration:0, 1, 3, 10, and 30 μM Incubation Time:1 hours Result:Inhibited RANKL-induced phosphorylation of JNK without decrease of the phosphorylation of ERK and p38 MAPK.

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Apoptosis

PERK

ERK

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189689-32-5

286.27

C16H14O5

>98% (HPLC)

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COc1cc2O[C@@H](CC(=O)c2cc1O)c1ccc(O)cc1

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(-20℃)

With Ice Pack

≥ 2 years