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GPI-1485
CAS No. 186268-78-0
GPI-1485( GM1485 )
Catalog No. M28922 CAS No. 186268-78-0
GPI-1485 (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 144 | In Stock |
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| 5MG | 128 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 359 | In Stock |
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| 50MG | 523 | In Stock |
|
| 100MG | 739 | In Stock |
|
| 200MG | 1088 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGPI-1485
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NoteResearch use only, not for human use.
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Brief DescriptionGPI-1485 (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.
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DescriptionGPI-1485 (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.(In Vitro):GPI-1485 induced cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF) .(In Vivo):GPI-1485 (5 mg/kg; intraperitoneal injection; 6-week period of daily) improved long-term neurological recovery in rats
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In VitroGPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF). Cell Viability Assay Cell Line:Normal human dermal fibroblasts (NHDF)Concentration:100 μM Incubation Time:Result:Induced cellular reprogramming and neural cell induction.
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In VivoGPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats. Animal Model:Adult male Wistar rats, weighing 250-300 g Dosage:5 mg/kg Administration:Intraperitoneal injection; daily; for a total of 42 days Result:Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats.
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SynonymsGM1485
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PathwayOthers
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TargetOther Targets
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RecptorUSP8
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Research Area——
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Indication——
Chemical Information
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CAS Number186268-78-0
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Formula Weight241.287
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Molecular FormulaC12H19NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (414.46 mM)
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SMILESCCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhiyu Li, et al. USP8 inhibitor and preparation method and application thereof. CN111138358A.
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