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6,6'-Dithiodinicotinic Acid

CAS No. 15658-35-2

6,6'-Dithiodinicotinic Acid( —— )

Catalog No. M28914 CAS No. 15658-35-2

6,6'-Dithiodinicotinic Acid is a non permeant thiol agent which affects several mitochondrial functions. In rat liver mitochondria, 6,6'-Dithiodinicotinic Acid inhibits only the Pi/OH- carrier; both 6,6'-Dithiodinicotinic Acid and n-butylmalonate are necessary to inhibit completely Pi entry.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    6,6'-Dithiodinicotinic Acid
  • Note
    Research use only, not for human use.
  • Brief Description
    6,6'-Dithiodinicotinic Acid is a non permeant thiol agent which affects several mitochondrial functions. In rat liver mitochondria, 6,6'-Dithiodinicotinic Acid inhibits only the Pi/OH- carrier; both 6,6'-Dithiodinicotinic Acid and n-butylmalonate are necessary to inhibit completely Pi entry.
  • Description
    6,6'-Dithiodinicotinic Acid is a non permeant thiol agent which affects several mitochondrial functions. In rat liver mitochondria, 6,6'-Dithiodinicotinic Acid inhibits only the Pi/OH- carrier; both 6,6'-Dithiodinicotinic Acid and n-butylmalonate are necessary to inhibit completely Pi entry.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Ferroptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    15658-35-2
  • Formula Weight
    308.33
  • Molecular Formula
    C12H8N2O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (405.41 mM)
  • SMILES
    OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen X, et al. Inhibiting Ferroptosis through Disrupting the NCOA4-FTH1 Interaction: A New Mechanism of Action. ACS Cent Sci. 2021 Jun 23;7(6):980-989.
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