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Rasarfin
CAS No. 674359-73-0
Rasarfin( —— )
Catalog No. M28668 CAS No. 674359-73-0
Rasarfin inhibits Ras and ARF6.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 204 | In Stock |
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| 50MG | 333 | In Stock |
|
| 100MG | 475 | In Stock |
|
| 200MG | 641 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRasarfin
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NoteResearch use only, not for human use.
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Brief DescriptionRasarfin inhibits Ras and ARF6.
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DescriptionRasarfin inhibits Ras and ARF6.(In Vitro):Rasarfin resulted in a dose-dependent reduction in cell growth in MDA-MB-231 cells.After 48 and 72 h of treatment, Rasarfin modestly decreased in a dose-dependent manner the metabolic activity of cancer cells compared to cells treated with DMSO.However, compared to Doxorubicin which potently killed cells, cell viability was not affected by Rasarfin treatment. Rasarfin inhibited proliferation of A549 lung cancer cells, which have increased Ras and EGFR activity52. Similar to the anti-proliferative effect on MDA-MB-231 cells, A549 cell growth inhibition at 5 and 10 μM of Rasarfin,more important cell viability effects of Rasarfin on A549 cells than MDA-MB-231 cells at 10 μM of Rasarfin treatment.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number674359-73-0
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Formula Weight425.91
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Molecular FormulaC23H24ClN3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (117.40 mM)
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SMILESCC(C)C(N(CC1)CCN1c(ccc(NC(c1cc(cccc2)c2o1)=O)c1)c1Cl)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang A, et al. Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
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