Thalidomide-NH-C2-PEG3-OH( H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- )

Catalog No. M28647 CAS No. 2140807-23-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Thalidomide-NH-C2-PEG3-OH
Note

Research use only, not for human use.
Brief Description

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate.
Description

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate.
In Vitro

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis.
In Vivo

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Synonyms

H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
Pathway

Others
Target

Other Targets
Recptor

CYP4A|20-Hydroxyeicosatetraenoic acid(20-HETE) synthesis
Research Area

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Indication

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1.Nakamura T, et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6.

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