VU0155094

CAS No. 731006-86-3

VU0155094( ML-397 | ML 397 | ML397 | VU-0155094 | VU 0155094 )

Catalog No. M28585 CAS No. 731006-86-3

ML397 is a positive allosteric modulator with differential activity at the various group III mGluRs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 219 Get Quote
10MG 312 Get Quote
25MG 527 Get Quote
50MG 754 Get Quote
100MG 1044 Get Quote
500MG 2088 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    VU0155094
  • Note
    Research use only, not for human use.
  • Brief Description
    ML397 is a positive allosteric modulator with differential activity at the various group III mGluRs.
  • Description
    ML397 is a positive allosteric modulator with differential activity at the various group III mGluRs.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ML-397 | ML 397 | ML397 | VU-0155094 | VU 0155094
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    731006-86-3
  • Formula Weight
    436.53
  • Molecular Formula
    C24H24N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (229.08 mM)
  • SMILES
    COC(=O)c1ccc(cc1)-n1c(C)cc(C(=O)CSc2ccc(NC(C)=O)cc2)c1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shaaban, Khaled A., Shaaban, Mohamed, Nair, Vimal, Schuhmann, Imelda, Win, Hnin Yu, Lei, Lei, Dittrich, Birger, Helmke, Elisabeth, Schüffler, Anja and Laatsch, Hartmut. "Structure elucidation and synthesis of hydroxylated isatins from Streptomycetes" Zeitschrift für Naturforschung B, vol. 71, no. 12, 2016, pp. 1191-1198.
molnova catalog
related products
  • Ginsenoside Ro

    GinsenosideRo exhibits a Ca2+-antagonistic antiplatelet effect.

  • Basimglurant

    Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).

  • VU6012962

    VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).