VU0155094
CAS No. 731006-86-3
VU0155094( ML-397 | ML 397 | ML397 | VU-0155094 | VU 0155094 )
Catalog No. M28585 CAS No. 731006-86-3
ML397 is a positive allosteric modulator with differential activity at the various group III mGluRs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 219 | Get Quote |
|
| 10MG | 312 | Get Quote |
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| 25MG | 527 | Get Quote |
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| 50MG | 754 | Get Quote |
|
| 100MG | 1044 | Get Quote |
|
| 500MG | 2088 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameVU0155094
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NoteResearch use only, not for human use.
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Brief DescriptionML397 is a positive allosteric modulator with differential activity at the various group III mGluRs.
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DescriptionML397 is a positive allosteric modulator with differential activity at the various group III mGluRs.
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In Vitro——
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In Vivo——
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SynonymsML-397 | ML 397 | ML397 | VU-0155094 | VU 0155094
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PathwayNeuroscience
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TargetGluR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number731006-86-3
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Formula Weight436.53
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Molecular FormulaC24H24N2O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (229.08 mM)
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SMILESCOC(=O)c1ccc(cc1)-n1c(C)cc(C(=O)CSc2ccc(NC(C)=O)cc2)c1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Ginsenoside Ro
GinsenosideRo exhibits a Ca2+-antagonistic antiplatelet effect.
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
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VU6012962
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
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