Thalidomide-O-amido-C4-NH2 TFA
CAS No. 1799711-25-3
Thalidomide-O-amido-C4-NH2 TFA( Cereblon Ligand-Linker Conjugates 6 TFA | E3 ligase Ligand-Linker Conjugates 19 TFA )
Catalog No. M28568 CAS No. 1799711-25-3
Thalidomide-O-amido-C4-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 30 | In Stock |
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| 10MG | 45 | In Stock |
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| 25MG | 73 | In Stock |
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| 50MG | 108 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameThalidomide-O-amido-C4-NH2 TFA
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NoteResearch use only, not for human use.
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Brief DescriptionThalidomide-O-amido-C4-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate.
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DescriptionThalidomide-O-amido-C4-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate.
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In Vitro——
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In Vivo——
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SynonymsCereblon Ligand-Linker Conjugates 6 TFA | E3 ligase Ligand-Linker Conjugates 19 TFA
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PathwayOthers
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TargetOther Targets
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RecptorBacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1799711-25-3
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Formula Weight516.43
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Molecular FormulaC21H23F3N4O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 42.86 mg/mL (82.99 mM)
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SMILESOC(=O)C(F)(F)F.NCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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NNMTi
NNMTi? is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM;?50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adipocytes 1-methylnicotinamide level (EC50 = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathwayNNMTi treatment will rescue age-related deficits in muSC activity to promote superior regeneration post-injury in aging muscle.
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THIP
THIP has a strong affinity for the δ subunit of GABAA receptors. THIP is a functionally selective GABAAR ligand, agonistic to α4β1δ, α4β3δ, and weakly antagonistic to αβγ and α4β2δ GABAARs.
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