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Protein kinase inhibitor H-7

CAS No. 84477-87-2

Protein kinase inhibitor H-7( -(5-Isoquinolinylsulfonyl)-2-methylpiperazine | 5-(2-methylpiperazine-1-sulfonyl)isoquinoline )

Catalog No. M28552 CAS No. 84477-87-2

Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Protein kinase inhibitor H-7
  • Note
    Research use only, not for human use.
  • Brief Description
    Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.
  • Description
    Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    -(5-Isoquinolinylsulfonyl)-2-methylpiperazine | 5-(2-methylpiperazine-1-sulfonyl)isoquinoline
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    Smoothened
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    84477-87-2
  • Formula Weight
    291.37
  • Molecular Formula
    C14H17N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (343.21 mM)
  • SMILES
    O=S(=O)(C1=CC=CC=2C=NC=CC21)N3CCNCC3C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15;7(6):1040-8.
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