Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate

Research use only, not for human use.

Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.

Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.(In Vitro):Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate (0-100 μM) inhibits the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner with the IC50 values of 10.93 μM and 16.43 μM, respectively. Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, whereas it inhibits SET7 by 90% at concentrations of 100 μM.

DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, while it inhibits SET7 by 90% at concentrations of 100 μM.DC-S239 (0-100 μM, 120 h) can inhibit the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner but no significant effect on the activity of HCT116 and DHL4 cells.Cell Viability Assay Cell Line:MCF7, HL60, DHL4, MV4-11 and HCT116 cell lines Concentration:0-100 μM Incubation Time:120 h Result:Inhibited MCF7 and HL60 with the IC50 values of 10.93 μM and 16.43 μM, respectively.

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DC-S239

Chromatin/Epigenetic

Histone Demethylase

D1

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303141-21-1

349.36

C15H15N3O5S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (357.80 mM)

CCOC(c1c(N)sc(C(Nc2cc([N+]([O-])=O)ccc2)=O)c1C)=O

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(-20℃)

With Ice Pack

≥ 2 years