SJ6986( —— )

Catalog No. M28351 CAS No. 2765625-93-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SJ6986
Note

Research use only, not for human use.
Brief Description

SJ6986 is a chemical probe for studying the role of GSPT1/2 in vitro and in vivo. SJ6986 supports the utility of a diverse library of CRBN binders in the pursuit of targeting undruggable oncoproteins.
Description

SJ6986 is a chemical probe for studying the role of GSPT1/2 in vitro and in vivo. SJ6986 supports the utility of a diverse library of CRBN binders in the pursuit of targeting undruggable oncoproteins.
In Vitro

SJ6986 exhibits EC50 values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively. Cell Proliferation Assay Cell Line:MV4-11 cells.Concentration:0-100 μM.Incubation Time:3 days.Result:Exhibited EC50 of 1.5 nM.Western Blot Analysis Cell Line:MV4-11 cells.Concentration:0-10 μM.Incubation Time:4 and 24 h.Result:Dose- and time-dependently decreased the protein levels of GSPT1.
In Vivo

SJ6986 exhibits t1/2 of 3.44 h by iv injection of 3 mg/kg and tmax of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

ABCG2
Research Area

——
Indication

——

CAS Number

2765625-93-0
Formula Weight

497.4
Molecular Formula

C20H14F3N3O7S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (201.05 mM)
SMILES

O=C(N1)CCC(N2C(C(C=C(NS(C3=C(OC(F)(F)F)C=CC=C3)(=O)=O)C=C4)=C4C2=O)=O)C1=O
Chemical Name

——

1.You Q, et al. Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma. J Agric Food Chem. 2021 Nov 3;69(43):12705-12716.

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