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Thalidomide-5-methyl
CAS No. 40313-92-6
Thalidomide-5-methyl( —— )
Catalog No. M28307 CAS No. 40313-92-6
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 132 | In Stock |
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| 5MG | 147 | In Stock |
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| 10MG | 221 | In Stock |
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| 25MG | 378 | In Stock |
|
| 50MG | 520 | In Stock |
|
| 100MG | 703 | In Stock |
|
| 200MG | 949 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameThalidomide-5-methyl
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NoteResearch use only, not for human use.
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Brief DescriptionThalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.
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DescriptionThalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorhDHODH
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Research Area——
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Indication——
Chemical Information
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CAS Number40313-92-6
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Formula Weight272.26
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Molecular FormulaC14H12N2O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCc(cc1)cc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lewis TA, et al. Development?of?ML390: A?Human?DHODH?Inhibitor?That?Induces?Differentiation?in?Acute?Myeloid?Leukemia. ACS Med Chem Lett.?2016 Sep 28;7(12):1112-1117.
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