ASP2453( —— )

Catalog No. M28235 CAS No. 2241719-73-1

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC 50 value of 40 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

ASP2453
Note

Research use only, not for human use.
Brief Description

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC 50 value of 40 nM.
Description

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC 50 value of 40 nM.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

——
Research Area

——
Indication

——

Chemical Information

CAS Number

2241719-73-1
Formula Weight

747.85
Molecular Formula

C40H48F3N7O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (334.29 mM)
SMILES

Cc(ccc1c2cn[nH]1)c2-c(c(C1CC1)cc(c1n2)c(N3CCC(C4)(CN4C(C=C)=O)CC3)nc2OC2CCN(CCCOC)CC2)c1OCC(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Abdolreza Hassanzadeh, et al. Mechanism for the degradation of erythromycin A and erythromycin A 2'-ethyl succinate in acidic aqueous solution. J Phys Chem A. 2007 Oct 11;111(40):10098-104.

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