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Home - Products - Endocrinology/Hormones - Opioid Receptor - EST73502

EST73502

CAS No. 2307458-82-6

EST73502( —— )

Catalog No. M28219 CAS No. 2307458-82-6

EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    EST73502
  • Note
    Research use only, not for human use.
  • Brief Description
    EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
  • Description
    EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.(In Vivo):In CD1 male mice, EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test. EST73502 (5 mg/kg; i.p.) attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Wnt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2307458-82-6
  • Formula Weight
    388.88
  • Molecular Formula
    C19H27ClF2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN1CC2(CCN(CCC3=CC(F)=CC=C3F)CC2)O[C@H](C)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528.
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