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EST73502
CAS No. 2307458-82-6
EST73502( —— )
Catalog No. M28219 CAS No. 2307458-82-6
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 285 | Get Quote |
|
| 10MG | 407 | Get Quote |
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| 25MG | 671 | Get Quote |
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| 50MG | 945 | Get Quote |
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| 100MG | 1251 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | 2547 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEST73502
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NoteResearch use only, not for human use.
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Brief DescriptionEST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
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DescriptionEST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.(In Vivo):In CD1 male mice, EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test. EST73502 (5 mg/kg; i.p.) attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorWnt
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Research Area——
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Indication——
Chemical Information
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CAS Number2307458-82-6
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Formula Weight388.88
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Molecular FormulaC19H27ClF2N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN1CC2(CCN(CCC3=CC(F)=CC=C3F)CC2)O[C@H](C)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528.
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