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JKE-1674

CAS No. 2421119-60-8

JKE-1674( —— )

Catalog No. M28123 CAS No. 2421119-60-8

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JKE-1674
  • Note
    Research use only, not for human use.
  • Brief Description
    JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
  • Description
    JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.(In Vitro):JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors.(In Vivo):JKE-1674 (50 mg/kg; p.o.) could be detected in the serum of mice dosed orally with the compound.
  • In Vitro
    JKE-1674 exhibits activity indistinguishable from that of ML210 in cellular target engagement assays including yielding the same +434Da GPX4 adduct in cells. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML210 and is completely rescued by ferroptosis inhibitors. JKE-1674 forms a nitrile-oxide electrophile in cells. JKE-1674 dehydration yields a nitrile-oxide electrophile that binds GPX4. JKE-1674 exhibits far greater stability than chloroacetamide inhibitors.
  • In Vivo
    JKE-1674 (50?mg/kg; p.o.) can be detected in the serum of mice dosed orally with the compound. Animal Model:SCID mice Dosage:50?mg/kg (Pharmacokinetic Analysis)Administration:P.o.Result:Could be detected in the serum of mice dosed orally with the compound.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IL-5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2421119-60-8
  • Formula Weight
    451.3
  • Molecular Formula
    C20H20Cl2N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (221.58 mM)
  • SMILES
    O=C(C(C[N+]([O-])=O)=NO)N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ian D Pavord, From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases. Allergy. 2022 Mar;77(3):778-797.
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