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JKE-1674
CAS No. 2421119-60-8
JKE-1674( —— )
Catalog No. M28123 CAS No. 2421119-60-8
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 120 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 174 | In Stock |
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| 25MG | 297 | In Stock |
|
| 50MG | 454 | In Stock |
|
| 100MG | 732 | In Stock |
|
| 200MG | 995 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJKE-1674
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NoteResearch use only, not for human use.
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Brief DescriptionJKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
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DescriptionJKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.(In Vitro):JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors.(In Vivo):JKE-1674 (50 mg/kg; p.o.) could be detected in the serum of mice dosed orally with the compound.
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In VitroJKE-1674 exhibits activity indistinguishable from that of ML210 in cellular target engagement assays including yielding the same +434Da GPX4 adduct in cells. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML210 and is completely rescued by ferroptosis inhibitors. JKE-1674 forms a nitrile-oxide electrophile in cells. JKE-1674 dehydration yields a nitrile-oxide electrophile that binds GPX4. JKE-1674 exhibits far greater stability than chloroacetamide inhibitors.
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In VivoJKE-1674 (50?mg/kg; p.o.) can be detected in the serum of mice dosed orally with the compound. Animal Model:SCID mice Dosage:50?mg/kg (Pharmacokinetic Analysis)Administration:P.o.Result:Could be detected in the serum of mice dosed orally with the compound.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorIL-5
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Research Area——
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Indication——
Chemical Information
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CAS Number2421119-60-8
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Formula Weight451.3
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Molecular FormulaC20H20Cl2N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (221.58 mM)
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SMILESO=C(C(C[N+]([O-])=O)=NO)N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CAY10465
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
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5-Methyl-2-thiophene...
5-Methyl-2-thiophenecarboxaldehyde is a candidate microscopic third-order nonlinear optical (NLO) material.
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Humanin (human)
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG.
