L-Allylglycine

Research use only, not for human use.

L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.

L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.(In Vitro):L-allylglycine inhibits glutamic acid decarboxylase(GAD) only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor.(In Vivo):The stereoisomers of allylglycine were injected into the posterior hypothalamus at a site also shown to be reactive to bicuculline. Injection of L-allylglycine but not D-allylglycine caused substantial increases in heart rate but only slight increases in blood pressure.

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(S)-(-)-2-Amino-4-pentenoic acid

Metabolic Enzyme/Protease

Dehydrogenase

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16338-48-0

115.132

C5H9NO2

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (434.29 mM)

N[C@@H](CC=C)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years