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NSC622608
CAS No. 2593254-90-9
NSC622608( —— )
Catalog No. M28030 CAS No. 2593254-90-9
NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 113 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 297 | In Stock |
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| 50MG | 439 | In Stock |
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| 100MG | 631 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC622608
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NoteResearch use only, not for human use.
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Brief DescriptionNSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.
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DescriptionNSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.(In Vitro):NSC622608 blocked VISTA signaling in vitro, enhanced T-cell proliferation, and restored T-cell activation in the presence of VISTA-expressing cancer cell lines.
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In VitroNSC622608 disrupts VISTA-VSIG-3 interaction with an IC50 value of 9.7 ± 0.3 μM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAntifection|MMP|Leishmania tropica
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Research Area——
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Indication——
Chemical Information
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CAS Number2593254-90-9
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Formula Weight322.24
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Molecular FormulaC9H12BrN3OS2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (129.31 mM)
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SMILESCN(C)C(SS1)=NC1=NCC2=CC=CO2.[H]Br
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Olaf Kunert, et al. Antiplasmodial and leishmanicidal activity of biflavonoids from Indian Selaginella bryopteris. Phytochemistry Letters,2008,1(4):171-4.
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