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Tofisopam

CAS No. 22345-47-7

Tofisopam( Emandaxin | Grandaxin )

Catalog No. M28018 CAS No. 22345-47-7

Tofisopam is a 2,3-benzodiazepine derivative with anti-anxiety property.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tofisopam
  • Note
    Research use only, not for human use.
  • Brief Description
    Tofisopam is a 2,3-benzodiazepine derivative with anti-anxiety property.
  • Description
    Tofisopam is a 2,3-benzodiazepine derivative with anti-anxiety property.(In Vivo):Tofisopam (30 and 100 mg/kg, po) significantly inhibited the gastric ulceration induced by water-immersion stress in normal rats in a dose-dependent manner. Immobilization-stress loading increased the incidence and average index of gastric ulceration in OB rats, compared with nonstressed rats. Tofisopam (100 mg/kg, po) significantly inhibited the gastric ulceration induced by stress loading in OB rats. Water-immersion stress loading induced a significant increase in intestinal propulsion in rats. This increase was reversed to control levels by tofisopam (100 mg/kg, po). Tofisopam (1.0 mg/kg, iv, or 0.1 mg/kg by intracerebrospinal injection) inhibited the constriction of ear microvessels, the decrease in earlobe temperature, and mydriasis induced by electrical stimulation of the medial hypothalamic area in rabbits.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Emandaxin | Grandaxin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HIV|clathrin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    22345-47-7
  • Formula Weight
    382.46
  • Molecular Formula
    C22H26N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCC1c2cc(OC)c(OC)cc2C(=NN=C1C)c1ccc(OC)c(OC)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lisa von Kleist, et al. Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell. 2011 Aug 5;146(3):471-84.
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