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Fosifloxuridine nafalbenamide
CAS No. 1332837-31-6
Fosifloxuridine nafalbenamide( NUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide )
Catalog No. M28004 CAS No. 1332837-31-6
NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 211 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 217 | In Stock |
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| 25MG | 392 | In Stock |
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| 50MG | 538 | In Stock |
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| 100MG | 737 | In Stock |
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| 200MG | 1004 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFosifloxuridine nafalbenamide
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NoteResearch use only, not for human use.
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Brief DescriptionNUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity.
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DescriptionNUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.
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In VitroFosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1).
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In VivoFosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models.
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SynonymsNUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorhLigI
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Research Area——
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Indication——
Chemical Information
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CAS Number1332837-31-6
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Formula Weight631.55
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Molecular FormulaC29H30F2N4O8P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (162.99 mM)
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SMILESC[C@H](N[P](O)(=O)(OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O)c1cccc2ccccc12)C(=O)OCc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.
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