Dimethindene

Research use only, not for human use.

Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.

Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.(In Vitro):In follicle-enclosed Xenopus oocytes, Dimethindene (5-500 μM) decreases Cromakalim cromakalim-induced K+ currents (IC50 = 29.5 μM).(In Vivo):In C57BL/6 mice with skin wound healing, Dimethindene (0.25 mg; i.p.) impairs cutaneous wound healing and delays skin wound closure.

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM.

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure. Animal Model:C57BL/6 mice with skin WH Dosage:0.25 mg Administration: intraperitoneal injection; once Result:Delayed skin wound closure as compared to vehicle treated mice.

Dimetindene | Dimetindeno

Others

Other Targets

Hedgehog|Apoptosis

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5636-83-9

292.426

C20H24N2

>98% (HPLC)

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CC(C1=C(CCN(C)C)Cc2ccccc12)c1ccccn1

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(-20℃)

With Ice Pack

≥ 2 years