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TG6-129

CAS No. 1164464-14-5

TG6-129( TG6 129 | TG6129 )

Catalog No. M27930 CAS No. 1164464-14-5

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TG6-129
  • Note
    Research use only, not for human use.
  • Brief Description
    TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM.
  • Description
    TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TG6 129 | TG6129
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    estrogen receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1164464-14-5
  • Formula Weight
    491.57
  • Molecular Formula
    C20H18FN5O3S3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)\C=C\c3ccc(F)cc3)cc2)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368.
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