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PKUMDL-WQ-2101
CAS No. 304481-72-9
PKUMDL-WQ-2101( —— )
Catalog No. M27914 CAS No. 304481-72-9
PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | Get Quote |
|
| 10MG | 58 | Get Quote |
|
| 25MG | 125 | Get Quote |
|
| 50MG | 215 | Get Quote |
|
| 100MG | 372 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePKUMDL-WQ-2101
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NoteResearch use only, not for human use.
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Brief DescriptionPKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
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DescriptionPKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
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In VitroCell Viability Assay Cell Line:MDA-MB-468 cells Concentration:2.5 μM, 5.0 μM, 20 μM and 40 μM Incubation Time:24 hours Result:Caused cell cycle arrest.
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In VivoAnimal Model:NOD.CB17 Scid/J mice injected with MDA-MB-468 cellsDosage:5 mg/kg, 10 mg/kg, 20 mg/kg Administration:i.p; daily; for 30 days Result:Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPDE9A|PDE5A1|PDE1B|PDE4D2|PDE10A1|PDE2A
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Research Area——
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Indication——
Chemical Information
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CAS Number304481-72-9
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Formula Weight317.26
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Molecular FormulaC14H11N3O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (394.01 mM)
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SMILESO=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)C2=CC=C(O)C=C2O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.1. Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88(5):836-845.
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